silybum marianum monograph

Silymarin also contains fatty acids 5 and a flavanone dihydroquercetin (taxifolin), 6 also credited with medicinal effects. 2. Milk thistle has been investigated for its anti-inflammatory, antimicrobial, and CNS effects. The fruit of the milk thistle plant (Silybum marianum, family As- teraceae/Compositae) has been a liver support remedy for 2,000 years.1The standardized extract known as silymarin contains three flavonoids of the flavonol subclass. Name of the medicinal product. Silybum marianum, Silymarin, hepatoprotective remedy, antioxidant Received November 3, 2014. The monograph on Silybum marianum (St Mary’s Thistle or Milk Thistle) can be seen listed on the most recent ANPA Newsletter, and I have also attached the full monograph below (with permission from Eta Brand, ANPA President and Editor). ♦ provide a model monograph as a basis for countries and researchers to develop further monographs on good agricultural and collection practices (GACP) for other medicinal plants; ♦ protect the wild resources of medicinal plants, in particular Artemisia annua L., to ensure their sustainable use. Beauty & Radiance Support, Digestive Support, Liver & Cleanse Support. The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. The plant originates from mountains of the Mediterranean region, where it forms scrub on a rocky base. Silybum marianum. Silybin predominates, followed by silydianin and silychristin. This plant and the related entity italicized and indented above can be weedy or invasive according to the authoritative sources noted below.This plant may be known by one or more common names in different places, and some are listed above. In Germany, milk thistle seed extracts have been marketed for many years. Silybum marianum . Its use for liver disorders dates back to Pliny the Elder, a Roman naturalist, who described Powdered milk thistle extract United States Pharmacopeia (USP) Reference Standard; CAS Number: 84604-20-6; Synonym: Silybum marianum extract, Milk thistle extract; find USP-1443850 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Silymarin includes the individual flavonolignans silybin A and silybin B (two isomers, together referred to as silibinin 4), isosilybin A and isosilybin B (two isomers), silydianin, and silychristin. In the U.S. in 2000, milk thistle ranked 11th in sales of all herbal products sold in food, drug, and mass market outlets, reaching about $9 million in retail sales. Preliminary evidence suggests milk thistle may reduce side effects such as hepatotoxicity, nephrotoxicity, radiation-induced mucositis and dermatitis, … Milk thistle is considered a weed by most gardeners because of how fast it grows. Milk Thistle Monograph: (Silybum marianum) Alternative Medicine Review 1999 (Aug); 4 ( 4): 272–274 ~ FULL TEXT Silybum marianum (milk thistle) has been used for centuries as an herbal medicine for the treatment of liver disease. Research suggests that it can help protect liver cells against day-to-day toxins and damage. Milk thistle can grow to be over 10 … Plant Description: Milk Thistle (Silybum marianum) is generally found in dry, rocky soils in southern and western Europe and is commonly seen in California. [2–4] Silybum marianum contains silymarin, which is composed of the flavanolignans silybin, silydianin, and silychristine, with silybin being the most biologically active. 2. WHO Monographs on Selected Medicinal Plants, Vol. It is hardy to zone (UK) 7 and is not frost tender. It has been studied for use in allergic rhinitis, asthma, cancer treatment–related adverse effects, rheumatoid arthritis, type 2 diabetes, drug-induced hepatotoxicity, drug-induced nephrotoxicity, dyslipidemia, and thalassemia; however clinical trials supporting these uses are limited. European Union herbal monograph on Silybum marianum (L.) Gaertn., fructus 1. Missouri Botanical Garden. St. Louis, MO 63110 USA. 2: Fructus Silybi Mariae. The white veins found on the leaves were thought to represent the Virgin Mary's milk and therefore was used as a galactagogue . The mechanisms of action of Silymarin are as follows: Herbal monograph for Milk thistle includes parts used, how to use as an herbal medicine, dosage and contraindications. Plant Finder Database: Silybum marianum (Plant Finder, 12 November 2019). Plants for a Future Database: Silybum marianum (Plants For A Future, 12 November 2019). Qualitative and quantitative composition 1, 2 Silybum marianum (L.) Gaertner, fructus extract (according to HMPC Monograph) Other Notes Certified for the analytes listed below. Silybum marianum is a medicinal plant whose therapeutic his-tory dates back to 2000 years ago and was used as a hepatopro-tective medication to treat jaundice and enlarged liver and spleen. Silybum marianum has the energetics of a dry temperament, capable of removing obstructions through sweating and cleansing of the pores. CARDUUS MAR- silybum marianum seed pellet Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. Modern Medicinal Use. The fruit is a strongly compressed, elongate-obovate achene, about 6 to 8 mm long, 3 mm broad and 1.5 mm thick. In a study investigating the effects of this formula, by looking closer at the impact of the single extracts included, found that C. scolymus was able to … It has been naturalized in South America, North America, and Southern Australia and requires warm, dry soil to grow (1). Asteraceae] OVERVIEW Milk thistle preparations have been used in European medicine for over 2,000 years for the treatment of liver diseases. Formulations made with the seed of the plant are used to address biliary digestive complaints, toxic liver damage, and supportive treatment in chronic inflammatory liver disease and hepatic dirrhosis. Clinical Studies on Milk Thistle (Silybum marianum[L.] Gaertner) (cont.) Application Number or Monograph Citation Marketing Start Date Milk thistle herbal preparations are produced from the seeds of Silybum marianum (L.) Gaertn. To be specified for the individual finished product. Silybum marianum Common name: Milk Thistle. Ingredient Type:Botanical, Extract Also Known As: Silybum marianum extract, Silymarin, Mary thistle extract, Holy thistle extract Silybum marianum or milk thistle is a plant from the Asteraceae family, native to Southern Europe, parts of the Middle East, and Northern Africa. To retrieve all information on milk thistle (Silybum marianum), including data published post-approval, use the all studies query. The Legalon extract of Silybum marianum is known as MZ 80 and has been extensively researched over the past few decades to support liver health. Accepted for publication January 6, 2015. * Traditional Health Benefits of Milk Thistle. Intensive research in the hepatoprotectant (liver protecting) effects of milk thistle began about 40 years ago. Alternative Medicine Review Monographs Silybum marianum Description Silybum marianum (milk thistle) has been used for centuries as an herbal medicine for the treatment of liver disease. Generic Name: strychnos nux-vomica seed, silybum marianum seed, silicon dioxide, potassium phosphate, dibasic and sodium sulfate Dosage Form: tablet Disclaimer: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. DIDB drug monograph DDI summaries are composed when the drugs are first approved by the FDA and are based on data curated mainly from NDA reviews and drug labels. Herbal Monograph. It is a stout, annual or biennial plant which can reach heights of 6 feet. Ghaffari AR, Noshad H, Ostadi A, et al: The effects of milk thistle on hepatic fibrosis due to methotrexate in rat. ... Much of the modern day research has been conducted in Germany where it is an approved herb in The German Commission E Monographs. Silybum marianum is a member of the daisy family (Asteraceae) and is native to the Mediterranean. blessed milkthistle. Family: Asteraceae Part used: Fruit/Seed Constituents: Flavolignans (silymarin complex), flavonoids, volatile oil, bitter principle, mucilage Actions: Cholagogue, hepatic, hepatoprotective & hepatorestorative, galactagogue, demulcent Medical uses: Research has shown that it promotes the regeneration of diseased liver cells and protects them … Silybum marianum Milk Thistle. Phytother Res. Botanical Monographs The seed of the Milk Thistle ( Silybum marianum ) plant was considered a specific for stitches in the side. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Silybum marianum – St Mary’s Thistle Monograph (PDF link) Great work Maureen, and again, congratulations! Milk thistle (Silybum marianum) is a thorny plant presenting decorative leaves with a white pattern of veins and purple flower heads. variegated thistle. [Fam. Halitonic. 2006;20(12):1036-9. Silymarin is found in highest concentrations in the fruit portion of the plant but is also found in the leaves and seeds. 1.2.1 Utilization These herbs include Cynara scolymus, Taraxacum officinale, Silybum marianum, and Peumus boldus. See certificate for values and more details Phytochemicals: Silybin A+B (quantitative); Silicristin, Silidianin, Isosilibinin A, Isosilibinin B (qualitative) Silymarin counteracts the toxic effects of a wide variety of liver poisons, including alcohol, carbon tetrachloride (used widely in the dry-cleaning industry) acetaminophen and the death cap mushroom, which can cause death within a day. Devon EX7 9LX England. Silybum marianum(L.) Gaertn. Silybum marianum is a BIENNIAL growing to 1.2 m (4ft) by 1 m (3ft 3in) at a fast rate. Silybum marianum has been found to offer protective benefit against substances including carbon tetrachloride, ethanol, paracetamol-induced liver peroxidation cyclosporin, phenothiazine, a butyrophenone, erythromycin, amitriptyline and nortriptyline oestradiol, Amanita phalloides, tacrine, Iron overload [3]. It is in leaf all year, in flower from July to September, and the seeds ripen from August to October. spotted thistle. milk thistle. It has a shiny brown stem, 1-3 feet high, with several branches and prickly thorns. A 1985 German monograph on the use of Silybum marianum in homeopathy includes indications for diseases of the gall bladder and liver. 2005. Saller R, Brignoli R, Melzer J, Meier R. An updated systematic review with meta-analysis for the clinical evidence of silymarin. Milk thistle, Silybum marianum, is a tall edible plant and a member of the Aster family. It is a remedy for vertigo, deafness, stomach cramps, brain fog, intestinal worms and inflammation of the liver. 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